[123I]β‐CIT spect in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Identifieur interne : 004916 ( Main/Exploration ); précédent : 004915; suivant : 004917[123I]β‐CIT spect in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Auteurs : Walter Pirker [Autriche] ; Susanne Asenbaum [Autriche] ; Gerhard Bencsits [Autriche] ; Daniela Prayer [Autriche] ; Willibald Gerschlager [Autriche] ; Lüder Deecke [Autriche] ; Thomas Brücke [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-11.
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Abstract
Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [123I]β‐CIT. Overall striatal binding was significantly reduced in MSA (−51% of normal mean), PSP (−60%), CBD (−35%), and PD (−58%), without overlap with control values. Asymmetry of striatal β‐CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen–caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [123I]β‐CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.
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DOI: 10.1002/1531-8257(200011)15:6<1158::AID-MDS1015>3.0.CO;2-0
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uniqKey="Deecke L" first="Lüder" last="Deecke">Lüder Deecke</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Clinical Neurology, University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Wilhelminenspital der Stadt Wien, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1158">1158</biblScope><biblScope unit="page" to="1167">1167</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">745C4F1FD75C7ECCB6945B3DB081285C77715BC5</idno><idno type="DOI">10.1002/1531-8257(200011)15:6<1158::AID-MDS1015>3.0.CO;2-0</idno><idno type="ArticleID">MDS1015</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corticobasal degeneration</term><term>Dopamine transporter</term><term>Multiple system atrophy</term><term>Progressive supranuclear palsy</term><term>Single photon emission computed tomography</term><term>[123I]β‐CIT</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [123I]β‐CIT. Overall striatal binding was significantly reduced in MSA (−51% of normal mean), PSP (−60%), CBD (−35%), and PD (−58%), without overlap with control values. Asymmetry of striatal β‐CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen–caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [123I]β‐CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></region><name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name><name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name><name sortKey="Bencsits, Gerhard" sort="Bencsits, Gerhard" uniqKey="Bencsits G" first="Gerhard" last="Bencsits">Gerhard Bencsits</name><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><name sortKey="Deecke, Luder" sort="Deecke, Luder" uniqKey="Deecke L" first="Lüder" last="Deecke">Lüder Deecke</name><name sortKey="Gerschlager, Willibald" sort="Gerschlager, Willibald" uniqKey="Gerschlager W" first="Willibald" last="Gerschlager">Willibald Gerschlager</name><name sortKey="Prayer, Daniela" sort="Prayer, Daniela" uniqKey="Prayer D" first="Daniela" last="Prayer">Daniela Prayer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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